Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy
نویسندگان
چکیده
منابع مشابه
Liver Dysfunction Associated with Intravenous Methylprednisolone Pulse Therapy in Patients with Graves' Orbitopathy
Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment for the active phase of moderate to severe Graves' orbitopathy (GO). However, acute and severe liver damage has been reported during and after IVMP therapy. In this retrospective study, we investigated risk factors for liver dysfunction during and after IVMP therapy based on 175 Japanese patients with moderate to se...
متن کاملMethylprednisolone pulse therapy for patients with moderately severe Graves' orbitopathy: a prospective, randomized, placebo-controlled study.
OBJECTIVE To assess whether methylprednisolone (MP) pulse therapy is efficacious in the treatment of moderately severe Graves' orbitopathy (GO). DESIGN Prospective, placebo (PL)-controlled, double-blind, randomized study. METHODS Fifteen previously untreated patients with active, moderately severe GO participated in the study; 6 patients received MP and 9 patients a PL. Moderately severe di...
متن کاملMeta-analysis of methylprednisolone pulse therapy for Graves' ophthalmopathy.
A meta-analysis was performed to evaluate the efficacy of methylprednisolone pulse therapy for Graves' ophthalmopathy. Eight studies involving 376 patients were included. A higher effective rate was found for patients treated with intravenous glucocorticoids (IVGC) over oral glucocorticoids (OGC) (risk ratio [RR] = 1.48; 95% confidence interval [CI] = 1.18-1.86). The combined IVGC and orbital r...
متن کاملEffect of methylprednisolone pulse therapy with and without alendronate on biochemical markers of bone turnover in patients with Graves' ophthalmopathy.
INTRODUCTION Immunosuppression with glucocorticoids is the method of choice in the treatment of active Graves' ophthalmopathy (GO). However, glucocorticoid therapy may have side effects, among others, it affects bone metabolism. OBJECTIVES The aim of the study was to compare the effect of methylprednisolone pulse therapy (MPPT) with and without alendronate on bone turnover markers in patien...
متن کاملGraves' Orbitopathy
1Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan 2Department of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Penrith, NSW 2751, Australia 3Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, 55101 Mainz, Germany ...
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ژورنال
عنوان ژورنال: International Journal of Endocrinology
سال: 2018
ISSN: 1687-8337,1687-8345
DOI: 10.1155/2018/1978590